Matambudziko ethyroid ari kupararira munharaunda yemazuva ano, achikanganisa vanhurume nevanhukadzi nevemazera akasiyana-siyana. Kuongororwa kwechirwere ichi kunogona kushaikwa kakawanda kupfuura mamwe mamiriro ezvinhu uye kurapwa/kunyorerwa mishonga ye thyroid kwava nemakore akawanda mushure mekunzwisisa kwesainzi chirwere ichi.
Mubvunzo watichapindura munyaya ino ndewekuti - Kurapa nechiedza kunogona here kubatsira mukudzivirira nekurapa matambudziko ethyroid/kusashanda zvakanaka kwemuviri?
Tichitarisa mumabhuku esainzi tinoona kutikurapwa kwechiedzaMhedzisiro yekushanda kwethyroid yakadzidzwa kakawanda, muvanhu (semuenzaniso Höfling DB et al., 2013), mbeva (semuenzaniso Azevedo LH et al., 2005), tsuro (semuenzaniso Weber JB et al., 2014), pakati pevamwe. Kuti tinzwisise chikonzero neikurapwa kwechiedzazvingangofadza vaongorori ava, kana kuti kwete, kutanga tinofanira kunzwisisa zvinhu zvekutanga.
Nhanganyaya
Hypothyroidism (thyroid shoma, thyroid isingashande zvakanaka) inofanira kuonekwa sedambudziko rinowanikwa nemunhu wese, pane chirwere chedema kana chena chinongosangana nevanhu vakuru chete. Hapana munhu munharaunda yemazuva ano ane huwandu hwakanaka hwemahormone ethyroid (Klaus Kapelari et al., 2007. Hershman JM et al., 1993. JM Corcoran et al., 1977.). Kuwedzera pakuvhiringidzika, kune zvikonzero zvakasiyana-siyana nezviratidzo nezvimwe zvinetso zve metabolic zvakaita sechirwere cheshuga, chirwere chemwoyo, IBS, cholesterol yakakwira, kushungurudzika uye kunyange kurasikirwa nebvudzi (Betsy, 2013. Kim EY, 2015. Islam S, 2008, Dorchy H, 1985.).
Kuva ne'slow metabolism' chaizvoizvo chinhu chimwe chete nehypothyroidism, ndosaka ichienderana nemamwe matambudziko mumuviri. Inongoonekwa chete se clinical hypothyroidism kana yasvika padanho rakaderera.
Muchidimbu, hypothyroidism idambudziko rekushaya simba mumuviri wese nekuda kwekushanda kwemahormone ethyroid mashoma. Zvikonzero zvinowanzo kuve zvakaoma, zvinosanganisira zvinhu zvakasiyana-siyana zvekudya uye mararamiro zvakaita se; kushushikana, nhaka, kukwegura, mafuta akawanda asina kuguta, kudya makabhohaidhiretsi mashoma, kudya macalorie mashoma, kushaya hope, kudhakwa, uye kunyange kurovedza muviri zvakanyanya. Zvimwe zvinhu zvakaita sekuvhiyiwa kwekubvisa thyroid, kudya fluoride, mishonga yakasiyana-siyana, nezvimwewo zvinokonzerawo hypothyroidism.
Kurapa kwakareruka kunogona kubatsira vanhu vane chirwere chethyroid chisina simba?
Chiedza chitsvuku neinfrared (600-1000nm)zvinogona kubatsira pakugadzirisa muviri mumuviri pamatanho akasiyana-siyana.
1. Dzimwe ongororo dzinogumisa kuti kushandisa chiedza chitsvuku zvakakodzera kunogona kuvandudza kugadzirwa kwemahormone. (Höfling et al., 2010,2012,2013. Azevedo LH et al., 2005. Вера Александровна, 2010. Gopkalova, I. 2010.) Kufanana nechero nyama mumuviri, thyroid gland inoda simba kuti iite mabasa ayo ese. Sezvo thyroid hormone iri chinhu chakakosha mukusimudzira kugadzirwa kwesimba, unogona kuona kuti kushomeka kwayo mumasero egland kunoderedza sei kugadzirwa kwehormone yethyroid - kutenderera kwakajairika. thyroid yakaderera -> simba shoma -> thyroid yakaderera -> nezvimwewo.
2. Kurapa kwechiedzaKana ikashandiswa zvakanaka pamutsipa inogona kukanganisa kutenderera uku kwakaipa, mudzidziso nekuvandudza kuwanikwa kwesimba remunzvimbo, nokudaro ichiwedzera kugadzirwa kwemahormone ethyroid echisikigo negland zvakare. Kana gland rethyroid rava neutano hwakanaka, pane zvakawanda zvakanaka zvinoitika, sezvo muviri wese pakupedzisira uchiwana simba raunoda (Mendis-Handagama SM, 2005. Rajender S, 2011). Kuumbwa kwehormone yeSteroid (testosterone, progesterone, nezvimwewo) kunomuka zvakare - mafungiro, chido chemuviri uye simba zvinowedzerwa, tembiricha yemuviri inowedzera uye zviratidzo zvese zve metabolism yakaderera zvinodzoserwa kumashure (Amy Warner et al., 2013) - kunyangwe chitarisiko chemuviri uye kukwezva pabonde zvinowedzera.
3. Pamwe chete nemabhenefiti anogona kuwanikwa mumuviri kubva pakusangana nethyroid, kuisa chiedza chero kupi zvako mumuviri kunogonawo kupa mhedzisiro mumuviri, kuburikidza neropa (Ihsan FR, 2005. Rodrigo SM et al., 2009. Leal Junior EC et al., 2010). Kunyangwe masero matsvuku eropa asina mitochondria; maplatelet eropa, masero machena eropa uye mamwe marudzi emasero ari muropa ane mitochondria. Izvi chete zviri kudzidzwa kuti zvionekwe kuti zvingaderedza sei kuzvimba uye cortisol - hormone yekushushikana inodzivirira T4 -> T3 activation (Albertini et al., 2007).
4. Kana munhu akaisa chiedza chitsvuku panzvimbo dzakati dzemuviri (dzakadai seuropi, ganda, mazamu, maronda, nezvimwewo), vamwe vaongorori vanofunga kuti zvinogona kuwedzera simba renzvimbo yacho. Izvi zvinoratidzwa zvakanyanya nezvidzidzo zvekurapa chiedza pazvirwere zveganda, maronda nehutachiona, uko muzvidzidzo zvakasiyana-siyana nguva yekupora inogona kuderedzwa nechiedza chitsvuku kana che infrared(J. Ty Hopkins et al., 2004. Avci et al., 2013, Mao HS, 2012. Percival SL, 2015. da Silva JP, 2010. Gupta A, 2014. Güngörmüş M, 2009). Mhedzisiro yechiedza munharaunda inoita seyakasiyana asi ichienderana nekushanda kwechisikigo kwehormone yethyroid.
Dzidziso huru uye inogamuchirwa nevakawanda yekushandiswa zvakananga kwechiedza kurapa inosanganisira kugadzirwa kwesimba remasero. Mhedzisiro yacho inofungidzirwa kuti inonyanya kukonzerwa nekuparadzanisa nitric oxide (NO) kubva kuma enzymes e mitochondrial (cytochrome c oxidase, nezvimwewo). Unogona kufunga nezveNO semukwikwidzi anokuvadza okisijeni, sezvinoita carbon monoxide. NO inomisa kugadzirwa kwesimba mumasero, zvichiita kuti pave nenzvimbo inoparadza simba zvakanyanya, iyo iri pasi pemvura inowedzera cortisol/stress.Chiedza chitsvukuInofungirwa kudzivirira chepfu iyi ye nitric oxide, uye kushushikana kunokonzerwa nayo, nekubvisa kubva mu mitochondria. Nenzira iyi chiedza chitsvuku chinogona kufungidzirwa se 'kudzivirira kushushikana', pane kuwedzera simba nekukurumidza. Zviri kungobvumira mitochondria yemasero ako kuti ishande nemazvo nekuderedza migumisiro yekushushikana, nenzira isingawanzoitiki ne thyroid hormone chete.
Saka kunyange hazvo hormone yethyroid ichivandudza huwandu hwemitochondria uye kushanda kwayo, fungidziro pamusoro pekurapa nechiedza ndeyekuti inogona kuwedzera uye kuve nechokwadi chemhedzisiro yethyroid nekudzivisa mamorekuru asina kunaka ane chekuita nekushushikana. Panogona kunge paine dzimwe nzira dzinoverengeka dzisina kunanga dzinoshandiswa nethyroid nechiedza chitsvuku kuderedza kushushikana, asi hatizozvitauri pano.
Zviratidzo zvekushaya simba kwe metabolic rate/hypothyroidism
Kurova kwemoyo kwakaderera (pasi pe75 bpm)
Tembiricha yemuviri yakaderera, pasi pe98°F/36.7°C
Nguva dzose unonzwa kutonhora (kunyanya maoko nemakumbo)
Ganda rakaoma chero kupi zvako pamuviri
Pfungwa dzisina kugadzikana/dzakatsamwa
Kunzwa kushushikana / kuzvidya mwoyo
Utsi hwehuropi, musoro
Vhudzi/nzara dzinokura zvishoma nezvishoma
Matambudziko emudumbu (kuvhuvhuta, IBS, kuzvimba, chirungurira, nezvimwewo)
Kuita weti kakawanda
Kuda zvepabonde kwakaderera/kusavapo (uye/kana kusasimba kwekuita zvepabonde / kusanyatsoita mafuta enhengo yemukadzi)
Kukanganiswa kwembiriso/candida
Kuenda kumwedzi kusingaenderane, kunorema, kunorwadza
Kusabereka
Vhudzi rinotetepa/rinodzikira nekukurumidza. Vhudzi rinotetepa
Kurara zvisina kunaka
Sisitimu ye thyroid inoshanda sei?
Homoni yethyroid inotanga kugadzirwa mugland yethyroid (iri mumutsipa) seT4, uye yozofamba neropa ichienda kuchiropa nedzimwe nyama, uko inoshandurwa kuita fomu inoshanda zvakanyanya - T3. Iyi mhando inoshanda zvakanyanya yehomoni yethyroid inobva yaenda kumasero ese emuviri, ichishanda mukati memasero kuvandudza kugadzirwa kwesimba remasero. Saka gland yethyroid -> chiropa -> masero ese.
Chii chinowanzo kanganisa mukugadzirwa uku? Muchikamu chekushanda kwemahormone ethyroid, chero chinhu chinogona kukonzera dambudziko:
1. Gland re thyroid pacharo harigone kugadzira mahormone akakwana. Izvi zvinogona kukonzerwa nekushaikwa kwe iodine mukudya, kuwanda kwe polyunsaturated fatty acids (PUFA) kana goitrogens mukudya, kuvhiyiwa kwe thyroid kare, chirwere chinonzi 'autoimmune' chirwere cheHashimoto, nezvimwewo.
2. Chiropa hachigone 'kumutsa' mahormone (T4 -> T3), nekuda kwekushaikwa kweglucose/glycogen, cortisol yakawandisa, kukuvara kwechiropa nekuda kwekufuta, doro, zvinodhaka nehutachiona, simbi yakawandisa, nezvimwewo.
3. Masero anogona kunge asiri kutora mahormone aripo. Kutora kwemasero mahormone anoshanda ethyroid kunowanzo kukonzerwa nezvinhu zvekudya. Mafuta akawanda anodyiwa (kana kubva mumafuta akachengetwa ari kuburitswa panguva yekudzikira uremu) anotovhara mahormone ethyroid kuti asapinde mumasero. Glucose, kana shuga kazhinji (fructose, sucrose, lactose, glycogen, nezvimwewo), zvakakosha kuti mahormone anoshanda ethyroid atore uye ashandiswe nemasero.
Hormone yethyroid musero
Kana pasina chipingamupinyi chiripo pakugadzirwa kwemahormone ethyroid, uye anogona kusvika kumasero, anoshanda zvakananga uye zvisina kunanga pakufema mumasero - zvichikonzera oxidation yakazara yeglucose (mu carbon dioxide). Pasina hormone yethyroid yakakwana 'yekubatanidza' mapuroteni e mitochondrial, kufema hakugone kupera uye kazhinji kunoguma ne lactic acid pane mhedzisiro ye carbon dioxide.
Homoni yethyroid inoshanda pamitochondria nenucleus yemasero, zvichikonzera mhedzisiro yenguva pfupi uye refu inovandudza metabolism ye oxidative. Munucleus, T3 inofungidzirwa kuti inokanganisa kuratidzwa kwemajini mamwe, zvichikonzera mitochondria yakawanda/itsva. Pamitochondria iripo kare, ine simba rakananga rekuvandudza simba kuburikidza ne cytochrome oxidase, pamwe nekusunungura kufema kubva mukugadzirwa kweATP.
Izvi zvinoreva kuti glucose inogona kusundirwa munzira yekufema pasina chikonzero chekugadzira ATP. Kunyange zvazvo izvi zvingaita sekunge zvinotambisa, zvinowedzera huwandu hwecarbon dioxide inobatsira, uye zvinomisa kuunganidzwa kweglucose selactic acid. Izvi zvinogona kuonekwa zvakanyanya kune vane chirwere cheshuga, avo vanowanzowana lactic acid yakawanda zvichikonzera mamiriro anonzi lactic acidosis. Vanhu vazhinji vane hypothyroidism vanotoburitsa lactic acid yakawanda pavanenge vakazorora. Homoni yethyroid inoita basa rakananga mukuderedza mamiriro aya ane njodzi.
Homoni yethyroid ine rimwe basa mumuviri, richisanganiswa nevhitamini A necholesterol kugadzira pregnenolone - iyo inotangira mahormone ese esteroid. Izvi zvinoreva kuti huwandu hwakaderera hwethyroid hunokonzera huwandu hwakaderera hweprogesterone, testosterone, nezvimwewo. Huremu hwakaderera hwemunyu we bile hunoitikawo, nokudaro zvichikanganisa kugaya. Homoni yethyroid ingangove ndiyo homoni inonyanya kukosha mumuviri, inonzi inodzora mabasa ese akakosha uye manzwiro ehutano.
Pfupiso
Homoni yethyroid inoonekwa nevamwe se'hormone huru' yemuviri uye kugadzirwa kwayo kunonyanya kubva pagland yethyroid nechiropa.
Homoni yethyroid inoshanda inokurudzira kugadzirwa kwesimba remitochondrial, kuumbwa kwemamwe mahormone emitochondria, uye mahormone esteroid.
Hypothyroidism idambudziko rekushaya simba kwemasero rine zviratidzo zvakawanda.
Zvikonzero zvekudzikira kwethyroid zvinonetsa kunzwisisa, zvine chekuita nekudya uye mararamiro.
Kudya zvine makabhohaidhiretsi mashoma uye kudya zvine PUFA yakawanda ndizvo zvinonyanya kukonzera kuzvidya mwoyo.
Gyroidkurapwa kwechiedza?
Sezvo thyroid gland iri pasi peganda nemafuta emutsipa, pedyo ne infrared ndiyo mhando yechiedza inonyanya kudzidzwa pakurapa thyroid. Izvi zvine musoro sezvo ichipinza zvakanyanya kupfuura tsvuku inoonekwa (Kolari, 1985; Kolarova et al., 1999; Enwemeka, 2003, Bjordal JM et al., 2003). Zvisinei, tsvuku ine wavelength yakaderera se630nm yakaongororwa thyroid (Morcos N et al., 2015), sezvo iri thyroid isina kunyanya kuoneka.
Mirayiridzo inotevera inowanzo teverwa pakudzidza:
Ma LED/ma laser ane infrarediri muhuwandu hwe700-910nm.
100mW/cm² kana kuti simba riri nani
Mirayiridzo iyi yakavakirwa pahurefu hwemafungu hunoshanda muzvidzidzo zvataurwa pamusoro apa, pamwe nezvidzidzo zvekupinda kwenyama zvataurwawo pamusoro apa. Zvimwe zvezvinhu zvinokanganisa kupinda kwenyama zvinosanganisira; kupusha, simba, simba, kubata kwenyama, polarization uye kubatana. Nguva yekushandisa inogona kuderedzwa kana zvimwe zvinhu zvikavandudzika.
Kana simba rakakodzera, mwenje ye infrared LED inogona kukanganisa gland rese re thyroid, kubva kumberi kuenda kumashure. Mwenje mutsvuku unooneka pamutsipa unobatsirawo, kunyangwe mudziyo wakasimba uchizodiwa. Izvi zvinodaro nekuti tsvuku inooneka haipindi zvakanyanya sezvambotaurwa. Sekufungidzira kwakajeka, 90w+ red LEDs (620-700nm) dzinofanira kupa mabhenefiti akanaka.
Mamwe marudzi etekinoroji yekurapa nechiedzasekuti ma laser emhando yepasi akanaka, kana uchikwanisa kuzvitenga. Ma laser anowanzo dzidzwa mumabhuku kupfuura ma LED, zvisinei mwenje we LED unowanzoonekwa wakaenzana (Chaves ME et al., 2014. Kim WS, 2011. Min PK, 2013).
Marambi ekupisa, ma incandescent uye ma infrared saunas hazvibatsiri pakuvandudza metabolic rate / hypothyroidism. Izvi zvinokonzerwa ne wide beam angle, kupisa kwakanyanya/kusashanda zvakanaka uye kutambisa zvinhu.
Mutsetse Wekupedzisira
Chiedza chitsvuku kana cheinfraredkubva pa LED source (600-950nm) inodzidzwa kuti ionekwe pa thyroid.
Mazinga emahormone ethyroid anotariswa uye anoyerwa muongororo yega yega.
Sisitimu yethyroid yakaoma. Kudya uye mararamiro zvinofanirawo kugadziriswa.
Kurapa nemwenje we LED kana kuti LLLT kwakanyatsodzidzwa uye kunovimbisa kuchengetedzeka kwakanyanya. Ma LED e infrared (700-950nm) anodiwa munzvimbo iyi, tsvuku inooneka yakanakawo.