Chirwere cheAlzheimer, chirwere chinoenderera mberi nekuora kwetsinga, chinoonekwa kuburikidza nezviratidzo zvakaita sekurasikirwa nendangariro, aphasia, agnosia, uye kusashanda zvakanaka kwemuviri. Pachivanhu, varwere vaishandisa mishonga yekuderedza zviratidzo. Zvisinei, nekuda kwekusakwana uye migumisiro inogona kuwanikwa nemishonga iyi, vaongorori vakatendeukira kukurapa ne phototherapy isingakuvadzi, vachibudirira zvikuru mumakore achangopfuura.
Munguva pfupi yapfuura, chikwata chakatungamirwa naProfessor Zhou Feifan wekuBiomedical Engineering College yeHainan University chakaona kuti non-contact transcranial phototherapy inogona kuderedza zviratidzo zvechirwere uye kuwedzera kugona kwekufunga mumakonzo akwegura neane Alzheimer's. Izvi zvakawanikwa zvitsva, zvakaburitswa mumagazini inonzi Nature Communications, zvinopa nzira inovimbisa yekugadzirisa zvirwere zvinoderedza mashandiro etsinga.
Kunzwisisa Pathology yeAlzheimer's Disease
Chikonzero chaicho cheAlzheimer's hachisati chajeka, asi chinoratidzwa nekuungana kwemapuroteni e-beta-amyloid zvisina kujairika uye kutenderera kwemasero eropa, zvichikonzera kusashanda zvakanaka kwetsinga dzeropa uye kudzikira kweruzivo rwepfungwa. Uropi, senhengo inonyanya kushanda mumuviri, hunoburitsa tsvina yakawanda yetsinga dzeropa panguva yekushanda kwetsinga dzeropa. Kuunganidzwa kwakanyanya kwetsvina iyi kunogona kukuvadza tsinga dzeropa, zvichiita kuti dzibviswe zvakanaka kuburikidza ne lymphatic system.
Mitsipa yeropa yemeningeal lymphatic, yakakosha pakubuda kwemvura mutsinga dzemutsinga, inoita basa guru mukubvisa mapuroteni ane chepfu anonzi beta-amyloid, tsvina yemetabolism, uye kudzora mashandiro emuviri, zvichiita kuti ive chinangwa chekurapa.
Kukanganisa kwePhototherapy paAlzheimer's
Chikwata chaProfessor Zhou chakashandisa laser ye808 nm near-infrared kwemavhiki mana yekurapa ne non-contact transcranial phototherapy pambeva dzakwegura nedzeAlzheimer's. Kurapa uku kwakavandudza zvakanyanya mashandiro emasero e meningeal lymphatic endothelial, kwakavandudza lymphatic drainage, uye pakupedzisira kwakaderedza zviratidzo zvechirwere uye kwakavandudza mashandiro ekuziva mumambeva.
Kukurudzira Kushanda Kwetsinga kuburikidza nePhototherapy
Phtotherapy inogona kusimudzira nekuvandudza mashandiro etsinga dzeropa kuburikidza nenzira dzakasiyana-siyana. Semuenzaniso, maitiro ekudzivirira muviri anoita basa rakakosha muAlzheimer's pathology. Ongororo dzichangoburwa dzinoratidza kuti 532 nm green laser irradiation inogona kuwedzera mashandiro etsinga dzemuviri, zvichikonzera mashandiro emukati metsinga dzemukati, kuvandudza vascular dementia, uye kuwedzera simba rekuyerera kweropa uye zviratidzo zvekiriniki muvarwere veAlzheimer's. Kupenya kwetsinga dzeropa kwekutanga kwegreen laser kwakaratidza kuvandudzika kukuru mukupenya kweropa, kupenya kweplasma, kuunganidzwa kwemasero matsvuku eropa, uye bvunzo dzepfungwa.
Kurapa nechiedza che infrared ne infrared light (photobiomodulation) zvinoshandiswa munzvimbo dzemuviri (kumashure nemakumbo) kunogona kumutsa mashandiro ekudzivirira masero emuviri kana masero ekutanga, zvichibatsira pakurarama kwetsinga dzeropa uye kubatsira kwekushandiswa kwemajini.
Kukuvadzwa kwe oxidative inzira yakakosha yezvirwere mukukura kweAlzheimer's. Tsvagiridzo inoratidza kuti kupiswa kwechiedza chitsvuku kunogona kuwedzera mashandiro eATP mumasero, kukonzera shanduko yemetabolism kubva kuglycolysis kuenda kumabasa e mitochondrial mu inflammatory microglia inokanganiswa ne oligomeric beta-amyloid, kuwedzera mazinga e anti-inflammatory microglia, kuderedza pro-inflammatory cytokines, uye kuita kuti phagocytosis idzivirire kufa kwetsinga dzetsinga.
Kuvandudza kungwarira, kuziva, uye kutarisisa kwenguva refu ndeimwe nzira inoshanda yekuvandudza hupenyu hwevarwere vane Alzheimer. Vaongorori vakaona kuti kuratidzwa kwechiedza chebhuruu chine urefu hwemafungu mapfupi kunokanganisa mashandiro ekuziva uye kudzora manzwiro. Kuratidzwa kwechiedza chebhuruu kunogona kukurudzira mashandiro etsinga dzeuropi, kukanganisa mashandiro eacetylcholinesterase (AchE) uye choline acetyltransferase (ChAT), nokudaro zvichivandudza kugona kwekudzidza nekurangarira.
Migumisiro Yakanaka yePhototherapy paNeurons dzeUropi
Kutsvagurudza kuri kuramba kuchiwedzera kwakasimbisa mhedzisiro yakanaka yekurapa ne phototherapy pakushanda kwetsinga dzeuropi. Inobatsira kumutsa mashandiro ekudzivirira emasero emuviri, kukurudzira kutaura kwemajini ehupenyu hwetsinga, uye kuyera huwandu hweokisijeni hunoshanda mumitochondrial. Izvi zvakawanikwa zvinosimbisa hwaro hwakasimba hwekushandiswa kwekurapa ne phototherapy.
Zvichibva paruzivo urwu, MERICAN Optical Energy Research Center, pamwe chete nechikwata cheGerman nemayunivhesiti akawanda, tsvakiridzo, uye masangano ekurapa, vakaita ongororo yaisanganisira vanhu vane makore ari pakati pe30-70 vane dambudziko rekuziva zvishoma, ndangariro dzisingachanyanyi kudzika, kunzwisisa zvishoma uye kufunga zvakanaka, uye kugona kudzidza kwakaderera. Vatori vechikamu vakatevedzera mitemo yekudya uye mararamiro ane hutano pavaiitwa phototherapy muMERICAN health cabin, nemarudzi emishonga nematanho akafanana.
Mushure memwedzi mitatu yekuongororwa kwepfungwa, kuongororwa kwepfungwa, uye kuongororwa kwepfungwa, mhedzisiro yakaratidza kuvandudzwa kukuru muMMSE, ADL, uye HDS scores pakati pevashandisi vekurapa ne phototherapy mumakamuri ehutano. Vatori vechikamu vakanzwawo kutariswa kwakawedzerwa, kunaka kwekurara, uye kuzvidya mwoyo kwakaderera.
Zvakawanikwa izvi zvinoratidza kuti kurapa ne phototherapy kunogona kushanda senzira yekutsigira masero europi, kuderedza kuzvimba kweuropi nezvimwe zvirwere zvine chekuita nazvo, kunatsiridza kugona kuziva, uye kusimudzira ndangariro. Uyezve, zvinovhura nzira itsva dzekurapa ne phototherapy kuti dzive nzira yekudzivirira.
