Chirwere cheAlzheimer, chinofambira mberi neurodegenerative disorder, chinoratidzwa kuburikidza nezviratidzo zvakadai sekurasikirwa kwendangariro, aphasia, agnosia, uye kukanganisa kwehutungamiri hunoita. Sechivanhu, varwere vave vachivimba nemishonga yekuzorodza zviratidzo. Zvisinei, nekuda kwezvisingakwanisi uye zvinogona kuitika zvemishonga iyi, vatsvakurudzi vakaisa pfungwa dzavo kune isiri-invasive phototherapy, vachiwana kubudirira kukuru mumakore achangopfuura.
Nguva pfupi yadarika, chikwata chinotungamirwa naMuzvinafundo Zhou Feifan kubva kuBiomedical Engineering College yeHainan University chakaona kuti kusaonana netranscranial phototherapy kunogona kuderedza zviratidzo zvepathological uye kuwedzera kugona kwekuziva muchembere neAlzheimer's-abatwa nembeva. Ichi chinokatyamadza kutsvaga, chakaburitswa mujenari Nature Communications, chinopa zano rinovimbisa rekugadzirisa zvirwere neurodegenerative.
Kunzwisisa Chirwere cheAlzheimer's Pathology
Chikonzero chaicho cheAlzheimer chinoramba chisina kujeka, asi chinoratidzwa neabnormal beta-amyloid protein aggregation uye neurofibrillary tangles, zvichiita kuti neuronal dysfunction uye kuderera kwekuziva. Huropi, semutezo wemuviri unoshanda zvakanyanya, unoburitsa tsvina yakakosha yemetabolism panguva yekuita kweneural. Kuwedzera kuunganidza kwetsvina iyi kunogona kukuvadza neuroni, zvinoda kubviswa kwakanaka kuburikidza ne lymphatic system.
Iyo meningeal lymphatic midziyo, yakakosha kune yepakati tsinga system drainage, inoita basa rakakosha mukubvisa chepfu beta-amyloid mapuroteni, tsvina yemetabolism, uye kudzora maitiro ezvirwere zvemuviri, zvichiita kuti ive chinangwa chekurapa.
Phototherapy's Impact paAlzheimer's
Chikwata chaProfessor Zhou chakashandisa 808 nm padyo-infrared laser kwemavhiki mana asingabatanidzi transcranial phototherapy kune akura uye Alzheimer's mbeva. Kurapa uku kwakawedzera zvakanyanya kushanda kwemeningeal lymphatic endothelial masero, yakavandudza lymphatic drainage, uye pakupedzisira yakadzora zviratidzo zvepathological uye nekuvandudza mashandiro enjere mumakonzo.
Kukurudzira Neuronal Basa kuburikidza nePhototherapy
Phtotherapy inogona kuwedzera nekuvandudza neuronal basa kuburikidza nenzira dzakasiyana siyana. Semuenzaniso, immune system inoita basa rakakosha muAlzheimer's pathology. Zvidzidzo zvenguva pfupi yapfuura zvinoratidza kuti 532 nm green laser irradiation inogona kuwedzera immune cell kushanda, kukonzeresa nzira dzemukati mukati mekatikati neurons, kuvandudza vascular dementia, uye kuwedzera kuyerera kweropa uye zviratidzo zvekiriniki muvarwere veAlzheimer. Yekutanga yegirini laser vascular irradiation yakaratidza kuvandudzwa kwakanyanya muropa viscosity, plasma viscosity, tsvuku tsvuku yeropa kuunganidzwa, uye neuropsychological bvunzo.
Tsvuku uye infrared light therapy (photobiomodulation) inoshandiswa kunharaunda dzemuviri (kumashure nemakumbo) inogona kumisa masero edziviriro kana stem cell 'yemukati ekudzivirira nzira, zvichibatsira mukupona neuronal uye kunobatsira gene kutaura.
Oxidative kukuvara zvakare yakakosha pathological process mukukura kweAlzheimer. Tsvagiridzo inoratidza kuti mwenje dzvuku irradiation inogona kuwedzera cellular ATP chiitiko, inokurudzira shanduko yemetabolism kubva ku glycolysis kuenda ku mitochondrial chiitiko mukuzvimba microglia inobatwa ne oligomeric beta-amyloid, inosimudzira anti-inflammatory microglia mazinga, kuderedza pro-inflammatory cytokines, uye activate phagocytosis kudzivirira neuronal. rufu.
Kuvandudza kusvinura, kuziva, uye kutarisisa kwakasimba ndeimwe nzira inoshanda yekusimudzira hupenyu hwevarwere veAlzheimer. Vatsvaguri vakaona kuti kuratidzwa kune pfupi-wavelength mwenje webhuruu zvinokanganisa kugona kwekuziva uye kuzvidzora kwemanzwiro. Blue light irradiation inogona kukurudzira neural circuit chiitiko, inopesvedzera basa reacetylcholinesterase (AchE) uye choline acetyltransferase (Chat), nokudaro kuvandudza kugona kwekudzidza nekuyeuka.
Phototherapy's Positive Effects paBrain Neurons
Boka rinokura rekutsvagisa zvine chiremera rinosimbisa maitiro akanaka ephototherapy pane basa reuropi neuron. Inobatsira kumisikidza maseru edziviriro emukati medziviriro nzira, inosimudzira neuronal kupona gene kutaura, uye kuenzanisa mitochondrial reactive oxygen marudzi mazinga. Izvi zvakawanikwa zvinogadzira hwaro hwakasimba hwemakiriniki ekushandisa kwephototherapy.
Zvichienderana neruzivo urwu, MERICAN Optical Energy Research Center, yakabatana nechikwata cheGerman nemayunivhesiti mazhinji, tsvagiridzo, uye masangano ekurapa, yakaita ongororo yaisanganisira vanhu vane makore makumi matatu kusvika makumi manomwe vane hurema hwekuziva, kuderera kwendangariro, kuderedzwa kwekunzwisisa uye kutonga, uye kusagona kudzidza kwakaderera. Vatori vechikamu vakaomerera kumararamiro ezvekudya uye ane hutano pavanenge vachiitiswa phototherapy muMERICAN hutano kabhini, ine mhando dzemishonga dzinoenderana uye dosages.
Mushure memwedzi mitatu yekuongorora neuropsychological, kuongorora mamiriro epfungwa, uye kuongororwa kwekuziva, zvigumisiro zvakaratidza kuvandudzwa kukuru muMMSE, ADL, uye HDS scores pakati pevashandi vehutano cabin phototherapy. Vatori vechikamu vakawanawo kukwidziridzwa kwekutarisisa kwekuona, kunaka kwekurara, uye kuderera kwekushushikana.
Izvi zvakawanikwa zvinoratidza kuti phototherapy inogona kushanda semushonga unotsigira kudzora masero ehuropi, kuderedza neuroinflammation uye ane hukama pathologies, kunatsiridza cognition, uye kuwedzera ndangariro. Zvakare, inovhura nzira nyowani dzekuti phototherapy ishanduke kuita yekudzivirira nzira yekurapa.
